IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
N Caronni, F La Terza, FM Vittoria, G Barbiera… - Nature, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
M Tu, L Klein, E Espinet, T Georgomanolis, F Wegwitz… - Nature cancer, 2021 - nature.com
Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
[HTML][HTML] Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression
Y Zhu, JM Herndon, DK Sojka, KW Kim, BL Knolhoff… - Immunity, 2017 - cell.com
Tumor-associated macrophages (TAMs) are essential components of the cancer
microenvironment and play critical roles in the regulation of tumor progression. Optimal …
microenvironment and play critical roles in the regulation of tumor progression. Optimal …
Tumor-associated macrophages in pancreatic ductal adenocarcinoma: origin, polarization, function, and reprogramming
S Yang, Q Liu, Q Liao - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only
cured by surgical resection in its early stage, but there remains a relatively high possibility of …
cured by surgical resection in its early stage, but there remains a relatively high possibility of …
[HTML][HTML] Targeting tumor-associated macrophages to combat pancreatic cancer
The tumor microenvironment is replete with cells that evolve with and provide support to
tumor cells during the transition to malignancy. The hijacking of the immune system in the …
tumor cells during the transition to malignancy. The hijacking of the immune system in the …
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …
complex ecosystem that drives tumor progression; however, in-depth single cell …
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
Macrophage and neutrophil interactions in the pancreatic tumor microenvironment drive the pathogenesis of pancreatic cancer
Simple Summary The survival rates for patients with pancreatic adenocarcinoma are very
low. This dismal prognosis is due in part to late detection and early development of …
low. This dismal prognosis is due in part to late detection and early development of …
Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway
S Boyer, HJ Lee, N Steele, L Zhang, P Sajjakulnukit… - Elife, 2022 - elifesciences.org
The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell
types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages …
types and marked by extensive fibrosis and inflammation. Tumor-associated macrophages …
Roles of differently polarized macrophages in the initiation and progressionof pancreatic cancer
P Storz - Frontiers in immunology, 2023 - frontiersin.org
During development of pancreatic cancer macrophage-mediated inflammatory processes
and the formation of cancerous lesions are tightly connected. Based on insight from mouse …
and the formation of cancerous lesions are tightly connected. Based on insight from mouse …