Apoptosis (ie programmed cell death) plays a key role in maintaining reproductive function
in the ovary, mammary and prostate glands, uterus, and testis. The purpose of the present …

Recent data indicated that local production of Fas ligand (FasL) by cells of the eye and testis
may confer immune tolerance at these sites. In the present study, we examined the in vivo …

Immunohistochemical localization of the Fas antigen in the infant and adult human ovary
during follicular growth, regression, and atresia was examined by the avidin/biotin …

To clarify the Fas and Fas-ligand status of normal and molar trophoblast, the expression of
Fas and FasL by placental trophoblast populations in partial and complete hydatidiform …

Abstract The Fas (Apo-1/CD95) ligand (FasL) belongs to the tumor necrosis factor family and
acts through its receptor (FasR/Apo-1/CD95) to induce apoptosis in target cells. FasL is …

Trophoblasts, the fetal cells that line the villous placenta and separate maternal blood from
fetal tissue, express both Fas antigen and the tumor necrosis factor (TNF) receptor p55 …

PROBLEM: The low frequency of maternal immune responses to paternally inherited fetal
antigens raises the following question: What regulates the immunobiology of pregnancy …

Human endometrial epithelial cells undergo apoptosis immediately before the menstrual
period. Apoptotic signalling was analysed using human endometrial tissue and a human …

Chorioamnionitis is a common cause of premature birth and is associated with significant
morbidity and mortality in the mother and infant. Preterm birth shares similarities with …

The Fas/FasL system provides the major apoptotic mechanism for many cell types,
participating in cell turnover in hormone-dependent tissues. In the present study, we …