Intercellular communication is mediated by gap junction (GJ) membrane channels that allow
ions, small signalling molecules and metabolites (4 kDa) to move rapidly and directly …

Several different gap junction channel subunit isotypes, known as connexins, were
synthesized in a cell-free translation system supplemented with microsomal membranes to …

The biogenesis of connexins and their assembly into functional gap junction hemichannels
(connexons) was studied with the use of a cell-free transcription/translation system. Velocity …

As inferred from structural studies of isolated gap junctional plaques, assembly of gap
junctions is a multistage process involving:(1) noncovalent oligomerization of connexin …

Gap junction channels assemble as dodecameric complexes, in which a hexameric
connexon (hemichannel) in one plasma membrane docks end-to-end with a connexon in …

The formation of gap junctions is a multistep process that begins with synthesis in the
membrane of the endoplasmic reticulum (ER) of connexins (Cx), members of a highly …

For gap junction channels to function, their subunit proteins, referred to as connexins, have
to be synthesized and inserted into the cell membrane in their native configuration. Like …

Connexins, the proteins that form gap junction channels, are polytopic plasma membrane
(PM) proteins that traverse the plasma membrane bilayer four times. The insertion of five …

Gap junctions are plaque-like clusters of intercellular channels that mediate intercellular
communication. Each of two adjoining cells contains a connexon unit which makes up half of …

To study the organization of gap junctions in living cells, the connexin isotypes α1 (Cx43), β1
(Cx32) and β2 (Cx26) were tagged with the autofluorescent tracer green fluorescent protein …