This review highlights evidence for a role of the vagus nerve in the development of obesity
and how targeting the vagus nerve with neuromodulation or pharmacology can be used as a …

The communication between the gut and the brain is important for the control of energy
homeostasis. In response to food intake, enteroendocrine cells secrete gut hormones, which …

Food interacts with sensors all along the alimentary canal to provide the brain with
information regarding its composition, energy content, and beneficial effect. Vagal afferents …

Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient
assimilation and metabolism, it has long been known that its communication with the brain is …

Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant
degree of independent control over gastrointestinal functions, the central nervous system …

The hypothalamus is a center of food intake and energy metabolism regulation. Information
signals from peripheral organs are mediated through the circulation or the vagal afferent …

The regulation of energy and glucose balance contributes to whole-body metabolic
homeostasis, and such metabolic regulation is disrupted in obesity and diabetes. Metabolic …

Obesity is reaching epidemic proportions globally and represents a major cause of
comorbidities, mostly related to cardiovascular disease. The autonomic nervous system …

The vagal afferent pathway is the major neural pathway by which information about ingested
nutrients reaches the CNS and influences both GI function and feeding behavior. Vagal …

Vagus nerve stimulation (VNS) is now available as a treatment for epilepsy and treatment-
resistant depression. The vagus nerve plays a central role in satiety and short-term …