High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …

Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

Objective By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4,
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …

In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …

Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …

Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …

Aims/hypothesis Upregulation of the reactive oxygen species (ROS)-producing enzyme
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …

It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …