NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice
AH de Souza, LRB Santos, LP Roma… - Molecular and cellular …, 2017 - Elsevier
High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
Suppression of NADPH oxidase 2 substantially restores glucose‐induced dysfunction of pancreatic NIT‐1 cells
H Yuan, Y Lu, X Huang, Q He, Y Man, Y Zhou… - The FEBS …, 2010 - Wiley Online Library
Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …
NADPH oxidase 4 in mouse β cells participates in inflammation on chronic nutrient overload
B Holendová, Š Benáková, M Křivonosková… - …, 2024 - Wiley Online Library
Objective By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4,
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
N Li, B Li, T Brun, C Deffert-Delbouille, Z Mahiout… - Diabetes, 2012 - Am Diabetes Assoc
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …
been reported, along with controversial findings regarding its function. Here, the role of …
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
E Anvari, P Wikström, E Walum, N Welsh - Free radical research, 2015 - Taylor & Francis
In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …
Relationship of NADPH Oxidase-1 expression to beta cell dysfunction induced by inflammatory cytokines
J Weaver, DA Taylor-Fishwick - Biochemical and biophysical research …, 2017 - Elsevier
Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …
Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes
A Kowluru, RA Kowluru - Biochemical pharmacology, 2014 - Elsevier
Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …
Beta-cell-specific expression of nicotinamide adenine dinucleotide phosphate oxidase 5 aggravates high-fat diet-induced impairment of islet insulin secretion in mice
K Bouzakri, C Veyrat-Durebex, C Holterman… - Antioxidants & redox …, 2020 - liebertpub.com
Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …
Inhibition of NADPH oxidase-1 preserves beta cell function
JR Weaver, W Grzesik, DA Taylor-Fishwick - Diabetologia, 2015 - Springer
Aims/hypothesis Upregulation of the reactive oxygen species (ROS)-producing enzyme
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …
The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
X Wang, A Elksnis, P Wikström, E Walum, N Welsh… - PLoS …, 2018 - journals.plos.org
It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …