Theabrownin induces cell apoptosis and cell cycle arrest of oligodendroglioma and astrocytoma in different pathways

JY Fu, CX Jiang, MY Wu, RY Mei, AF Yang… - Frontiers in …, 2021 - frontiersin.org
Theabrownin (TB), a natural compound present in the fresh leaves of green tea, is a
potential antitumor agent. However, so far whether and how TB affects glioma is unclear. In …

Theabrownin inhibits cell cycle progression and tumor growth of lung carcinoma through c-myc-related mechanism

L Zhou, F Wu, W Jin, B Yan, X Chen, Y He… - Frontiers in …, 2017 - frontiersin.org
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage
but also a traditional Chinese medicine used for prevention or treatment of cancer, such as …

Anti-proliferative and apoptosis-inducing effect of theabrownin against non-small cell lung adenocarcinoma A549 cells

F Wu, L Zhou, W Jin, W Yang, Y Wang, B Yan… - Frontiers in …, 2016 - frontiersin.org
With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer
(NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia …

Onset of p53/NF‐κB signaling crosstalk in human melanoma cells in response to anti‐cancer theabrownin

T Li, B Yan, X Xiao, L Zhou, J Zhang, Q Yuan… - The FASEB …, 2022 - Wiley Online Library
As a major tea component, theabrownin represents a promising anti‐cancer candidate.
However, its effect on the melanoma is unknown. To evaluate the in vitro and in vivo anti …

Theabrownin induces apoptosis and tumor inhibition of hepatocellular carcinoma Huh7 cells through ASK1-JNK-c-Jun pathway

J Xu, B Yan, L Zhang, L Zhou, J Zhang… - OncoTargets and …, 2020 - Taylor & Francis
Purpose Theabrownin (TB), a main pigment and bioactive component of tea, has been
shown anti-tumor activities against carcinomas, but its effects on hepatocellular carcinoma …

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathway

W Jin, L Zhou, B Yan, L Yan, F Liu… - Journal of Cellular …, 2018 - Wiley Online Library
Osteosarcoma becomes the second leading cause of cancer death in the younger
population. Current outcomes of chemotherapy on osteosarcoma were unsatisfactory to …

Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms

W Jin, C Gu, L Zhou, X Yang, M Gui… - Oncology …, 2020 - spandidos-publications.com
Considering the high metastatic potential of osteosarcoma, not only pro‑apoptosis, but also
anti‑metastasis is important for anti‑osteosarcoma therapy. Previously, the authors reported …

Green tea-derived theabrownin suppresses human non-small cell lung carcinoma in xenograft model through activation of not only p53 signaling but also MAPK/JNK …

X Xiao, L Guo, W Dai, B Yan, J Zhang, Q Yuan… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance According to the theory and practice of traditional Chinese
medicine (TCM), the pathogenesis of lung carcinoma is associated with many syndromes …

Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling …

J Xu, X Xiao, B Yan, Q Yuan, X Dong, Q Du… - Cancer Cell …, 2022 - Springer
Background Theabrownin (TB) is a bioactive component of tea and has been reported to
exert effects against many human cancers, but its efficacy and mechanism on hepatocellular …

[HTML][HTML] Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

B Liu, YQ Gao, XM Wang… - Molecular medicine …, 2014 - spandidos-publications.com
Germacrone is one of the major bioactive components of the traditional Chinese Medicinal
plant Curcuma aromatica Salisb. and has been shown to possess anti‑tumor properties. In …