The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Abstract Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the
anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

A large body of clinical, genetic, and biochemical evidence indicates that cyclooxygenase-2
(COX-2), a key enzyme for prostanoid biosynthesis, contributes to the promotion of …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the
generation of biologically active eicosanoids. Eicosanoid expression levels vary during …

Although the incidence of gastric cancer has been declining in recent decades, it remains a
major public health issue as the second leading cause of cancer death worldwide. In China …

Cyclooxygenase (COX) and its prostanoid metabolites have been implicated in the control of
cell survival; however, their role as mitogens remains undefined. To better understand the …