Mitochondria: a therapeutic target in acute kidney injury
Y Ishimoto, R Inagi - Nephrology Dialysis Transplantation, 2016 - academic.oup.com
Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …
morbidity. It is a risk factor for the development and progression of chronic kidney disease …
Mitochondria in acute kidney injury
KM Ralto, SM Parikh - Seminars in nephrology, 2016 - Elsevier
Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and
health care expenditure. In the United States alone, it is estimated that more than $10 billion …
health care expenditure. In the United States alone, it is estimated that more than $10 billion …
Mitochondria as therapeutic targets in acute kidney injury
AM Hall, CD Schuh - Current opinion in nephrology and …, 2016 - journals.lww.com
Recent studies show that it is now eminently feasible to pharmacologically manipulate
various key aspects of mitochondrial biology in the kidney, and this has much potential for …
various key aspects of mitochondrial biology in the kidney, and this has much potential for …
[HTML][HTML] Targeting mitochondria and metabolism in acute kidney injury
Y Li, M Hepokoski, W Gu, T Simonson… - Journal of Clinical …, 2021 - mdpi.com
Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill
patients. AKI is also an independent risk factor for the development and progression of …
patients. AKI is also an independent risk factor for the development and progression of …
Mitochondria-targeted therapies for acute kidney injury
Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …
[HTML][HTML] The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential
X Zhang, E Agborbesong, X Li - International journal of molecular …, 2021 - mdpi.com
Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …
[HTML][HTML] Mitochondrial homeostasis in acute organ failure
LJ Stallons, JA Funk, RG Schnellmann - Current pathobiology reports, 2013 - Springer
Abstract The kidneys compose approximately 0.5% of the body mass but consume about
10% of the oxygen in cellular respiration. This discordance is due to the high energy …
10% of the oxygen in cellular respiration. This discordance is due to the high energy …
Role of mitochondrial therapy for ischemic-reperfusion injury and acute kidney injury
N Pabla, A Bajwa - Nephron, 2022 - karger.com
Acute kidney injury (AKI) is a common clinical disorder associated with decline in renal
function because of ischemic and nephrotoxic insults. The pathophysiology of AKI involves …
function because of ischemic and nephrotoxic insults. The pathophysiology of AKI involves …
[HTML][HTML] Mitochondrial dysfunction in kidney injury, inflammation, and disease: Potential therapeutic approaches
D Bhatia, A Capili, ME Choi - Kidney research and clinical practice, 2020 - ncbi.nlm.nih.gov
Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …
Mitochondrial metabolism in acute kidney injury
The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for
the active transport required to maintain water and solute reabsorption. Aberrations in …
the active transport required to maintain water and solute reabsorption. Aberrations in …