Acute kidney injury (AKI) is a global health concern associated with high morbidity and
mortality. AKI etiology is linked to mitochondrial dysfunction along with oxidative stress and …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction
caused by a dysregulated host response to infection. Severe patients always present with …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Sepsis and multiple organ failure remain leading causes of death in intensive care patients.
Recent advances in our understanding of the pathophysiology of these syndromes include a …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Mitochondrial dysfunctions are among the main hallmarks of several brain diseases,
including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells …

Background. Recent animal studies have shown that mitochondrial dysfunction initiates and
accelerates renal injury in sepsis, but its role in sepsis remains unknown. Mitochondrial …

Abstract Bax inhibitor-1 (BI1) conveys anti-apoptotic signals for mitochondria while prohibitin
2 (PHB2) is implicated in sustaining mitochondrial morphology and function. However, their …