Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Cell death by apoptosis or necrosis is often important in the etiology and treatment of
disease. Since mitochondria play important roles in cell death pathways, these organelles …

Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important
scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass …

Cardiomyocytes and neurons are highly susceptible to ischemia-reperfusion injury;
accordingly, considerable effort has been devoted to elucidating the cellular mechanisms …

Background Mitochondria are essential organelles that provide energy for cellular functions,
participate in cellular signaling and growth, and facilitate cell death. Based on their …

Background Sepsis-induced myocardial dysfunction is associated with worse clinical
outcomes and high mortality, but no effective therapeutic intervention has been explored …

Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

Acute kidney injury (AKI) contributes to the high morbidity and mortality of multi-system
organ failure in sepsis. However, recovery of renal function after sepsis-induced AKI …

Acute kidney injury (AKI) is a public health concern with an annual mortality rate that
exceeds those of breast and prostate cancer, heart failure, and diabetes combined …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in
the United States and many other countries. DKD occurs through a variety of pathogenic …