Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic …

D Sun, C Sun, G Qiu, L Yao, J Yu, H Al Sberi… - … Science and Pollution …, 2021 - Springer
Abstract Treatment with anti-neoplastic agents, including cyclophosphamide (CP), is
associated with several adverse reactions. Here, we distinguished the potential protective …

[HTML][HTML] Pterostilbene reduces acetaminophen-induced liver injury by activating the Nrf2 antioxidative defense system via the AMPK/Akt/GSK3β pathway

X Fan, L Wang, J Huang, H Lv, X Deng… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Pterostilbene (Pts), a natural dimethylated analog of resveratrol from
blueberries, exerts antioxidative and anti-apoptotic effects in various diseases. This study …

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway

L Wang, S Zhang, H Cheng, H Lv, G Cheng… - Free Radical Biology and …, 2016 - Elsevier
Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and
oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant …

Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver

B Nan, C Yang, L Li, H Ye, H Yan, M Wang… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) in heat-processed food leads to widespread concerns due to its
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …

Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis

Z Gao, H Zhan, W Zong, M Sun, L Linghu, G Wang… - Life Sciences, 2023 - Elsevier
Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of drug-
induced liver injury worldwide, which is significantly linked to oxidative stress and sterile …

Isoorientin induces Nrf2 pathway-driven antioxidant response through phosphatidylinositol 3-kinase signaling

JH Lim, HS Park, JK Choi, IS Lee, HJ Choi - Archives of pharmacal …, 2007 - Springer
Because oxidative stress is involved in the pathogenesis of various chronic diseases and
the aging process, antioxidants that can increase the intrinsic antioxidant potency are …

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway

P Shen, L Han, G Chen, Z Cheng, Q Liu - Inflammation, 2022 - Springer
Emodin is a natural bioactive compound from traditional Chinese herbs that exerts anti-
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …

[HTML][HTML] Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation

H Guo, J Sun, D Li, Y Hu, X Yu, H Hua, X Jing… - Biomedicine & …, 2019 - Elsevier
Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Carveol a naturally-derived potent and emerging Nrf2 activator protects against acetaminophen-induced hepatotoxicity

ZU Rahman, LT Al Kury, A Alattar, Z Tan… - Frontiers in …, 2021 - frontiersin.org
Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and
anti-inflammatory potential. However, APAP overdose sometimes causes severe liver …

[HTML][HTML] Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy

L Wang, W Wei, Q Xiao, H Yang, X Ci - International journal of …, 2019 - ncbi.nlm.nih.gov
Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is
involved in the prevention of hepatotoxicity. The purpose of the current study was to explore …