Acetaminophen (APAP) overdose may lead to the formation of oxidative stress, hepatocyte
apoptosis and necrosis, and, eventually result in acute liver failure. Escin, a major extracted …

Isolongifolene (ISO) has antioxidant, anti-inflammatory, anticancer, and neuroprotective
effects; however, it is unclear whether ISO has a protective effects against liver …

Acetaminophen (APAP) overdose is one of the most common causes of drug-induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Puerarin (Pue) is a kind of isoflavone compound extracted from Pueraria lobata, which has
significant antioxidant activity. Excessive use of acetaminophen (APAP) can cause oxidative …

Acetaminophen (APAP)-induced liver injury (AILI) is the main cause of acute liver failure in
the developed countries. The present study aimed to evaluate the therapeutic efficacy of …

Background Limonin, a bioactive compound from citrus plants, exerts antioxidant activities,
however its therapeutic potential in acetaminophen (APAP)-induced hepatotoxicity remains …

Ethnopharmacological relevance Oroxyloside is a natural flavonoid isolated from Scutellaria
baicalensis Georgi (Lamiaceae) which is a Chinese herb widely used for liver diseases …

Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

Acetaminophen (APAP) overdose is very common worldwide and has been widely
recognized as the leading cause of drug-induced liver injury in the Western world. In our …