In the last two decades, targeted protein degradation has rapidly gained popularity as a
technique to eliminate disease‐causing undruggable proteins. Over the years, many tools …

Targeted protein degradation is a promising therapeutic strategy capable of overcoming the
limitations of traditional occupancy-based inhibitors. By ablating all of the associated …

Targeted protein degradation (TPD) involving chimeric molecules has emerged as one of
the most promising therapeutic modalities in recent years. Among various reported TPD …

Traditional drug discovery mainly focuses on direct regulation of protein activity. The
development and application of protein activity modulators, particularly inhibitors, has been …

Targeted protein degradation refers to the use of small molecules to induce the selective
degradation of proteins. In its most common form, this degradation is achieved through …

The advent of multi-specific targeted protein degradation (TPD) therapies has made it
possible to drug targets that have long been considered to be inaccessible. For this reason …

A series of tools for targeted protein degradation are inspiring scientists to develop new
drugs with advantages over traditional small-molecule drugs. Among these tools, proteolysis …

Selective protein degradation platforms have afforded new development opportunities for
therapeutics and tools for biological inquiry. The first lysosome-targeting chimeras (LYTACs) …

Of late, targeted protein degradation (TPD) has surfaced as a novel and innovative chemical
tool and therapeutic modality. By co-opting protein degradation pathways, TPD facilitates …

Targeted protein degradation (TPD) is a recent strategy, utilizing the cell's proteostasis
machinery to deplete specific proteins. This represents a paradigm shift in early drug …