Simple Summary Gene inactivation is a powerful strategy to study the function of specific
proteins in the context of cellular physiology that can be applied for only non-essential …

Precise distribution of proteins is essential to sustain the viability of cells. A complex network
of protein synthesis and targeting factors cooperate with protein quality control systems to …

Targeted protein degradation is a rapidly exploding drug discovery strategy that uses small
molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin …

Infectious diseases remain a major burden to global health. Despite the implementation of
successful vaccination campaigns and efficient drugs, the increasing emergence of …

The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and
regulates fundamental cellular processes such as the cell cycle, cell signaling, and …

Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely
used strategy for treating malignant tumors. However, most intracellular proteins have been …

Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has
emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the …

Targeted protein degraders, known as proteolysis targeting chimeras (PROTACs), are
drawing more attention as next-generation drugs to target currently undruggable proteins …

The ability to selectively degrade proteins with bifunctional small molecules has the potential
to fundamentally alter therapy in a variety of diseases. However, the relatively large size of …

Membrane integrity is essential for cellular survival and function. The spectrum of
mechanisms protecting cellular and intracellular membranes is not fully known. Our recent …