Autophagy is a conserved catabolic process involved in the elimination of proteins,
organelles and pathogens. Autophagosome formation is the key process in autophagy …

The therapeutic modality of targeted protein degradation promises to overcome limitations of
traditional pharmacology. Small-molecule degraders recruit disease-causing proteins to E3 …

Target protein degradation has emerged as a promising strategy for the discovery of novel
therapeutics during the last decade. Proteolysis-targeting chimera (PROTAC) harnesses a …

The dawn of targeted degradation using proteolysis-targeting chimeras (PROTACs) against
recalcitrant proteins has prompted numerous efforts to develop complementary drugs …

Endocytosis is an essential process where proteins and lipids are internalised from the
plasma membrane in membrane-bound carriers, such as clathrin-coated vesicles. Once …

Highlights•Small molecule protein degraders (PROTACs) can target the 'undruggable'
proteome.•Ligands that bind the target anywhere on its surface can be used to make …

Targeted protein degradation (TPD) is a new pharmacology based on small-molecule
degraders that induce proximity between a protein of interest (POI) and an E3 ubiquitin …

The aberrant regulation of protein expression and function can drastically alter cellular
physiology and lead to numerous pathophysiological conditions such as cancer …

Recently, lysosome targeting chimeras (LYTACs) have emerged as a promising technology
that expands the scope of targeted protein degradation to extracellular targets. However, the …

Proteolysis targeting chimera (PROTAC) technology, the recruitment of E3 ubiquitin ligases
to induce the degradation of a protein target, is rapidly impacting chemical biology, as well …