Subclinical doses of ATP-sensitive potassium channel modulators prevent alterations in memory and synaptic plasticity induced by amyloid-β
K Salgado-Puga, J Rodriguez-Colorado… - Journal of …, 2017 - content.iospress.com
In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (K
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …
The K ATP channel activator diazoxide ameliorates amyloid-β and Tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease
Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium
dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP …
dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP …
Effects of Aβ1–42 on the Subunits of KATP Expression in Cultured Primary Rat Basal Forebrain Neurons
G Ma, Q Fu, Y Zhang, J Gao, J Jiang, A Bi, K Liu… - Neurochemical …, 2008 - Springer
ATP-sensitive potassium channels (K ATP) play a crucial role in coupling metabolic energy
to the membrane potential of cells, thereby functioning as cellular “metabolic sensors.” …
to the membrane potential of cells, thereby functioning as cellular “metabolic sensors.” …
Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease
L Wang, H Kang, Y Li, Y Shui, R Yamamoto, T Sugai… - …, 2015 - Elsevier
We previously showed that activity of the large conductance calcium-activated potassium
(Big-K; BK) channels is suppressed in 3xTg Alzheimer disease (AD) model mice. However …
(Big-K; BK) channels is suppressed in 3xTg Alzheimer disease (AD) model mice. However …
Inhibition of PKA attenuates memory deficits induced by β-amyloid (1–42), and decreases oxidative stress and NF-κB transcription factors
Alzheimer's disease (AD), the most relevant cause of dementia in elderly, is characterized by
amyloid β (Aβ) containing plaques and neurofibrillatory tangles, synaptic and neuronal loss …
amyloid β (Aβ) containing plaques and neurofibrillatory tangles, synaptic and neuronal loss …
Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying …
I Sánchez‐Rodríguez, S Djebari… - Journal of …, 2020 - Wiley Online Library
Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides+ thought to be
responsible for learning and memory impairments in Alzheimer's disease (AD) early stage …
responsible for learning and memory impairments in Alzheimer's disease (AD) early stage …
Diazoxide Reverses the Enhanced Expression of KATP Subunits in Cholinergic Neurons Caused by Exposure to Aβ1-42
G Ma, J Gao, Q Fu, L Jiang, R Wang, Y Zhang… - Neurochemical …, 2009 - Springer
The ATP-sensitive potassium channel (K ATP) play a crucial role in coupling metabolic
energy to the cell membrane potential, β-amyloid peptide (Aβ) neurotoxicity has been …
energy to the cell membrane potential, β-amyloid peptide (Aβ) neurotoxicity has been …
ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases
J Lv, X Xiao, M Bi, T Tang, D Kong, M Diao… - Ageing Research …, 2022 - Elsevier
ATP-sensitive potassium channels (K ATP channels), a group of vital channels that link the
electrical activity of the cell membrane with cell metabolism, were discovered on the …
electrical activity of the cell membrane with cell metabolism, were discovered on the …
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression-and anxiety-related symptoms in a rat model of Alzheimer's …
MH Esmaeili, B Bahari, AA Salari - Brain research bulletin, 2018 - Elsevier
Affective disorders including depression and anxiety are among the most prevalent
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …
[HTML][HTML] Amyloid β and amyloid precursor protein synergistically suppress large-conductance calcium-activated potassium channel in cortical neurons
K Yamamoto, R Yamamoto, N Kato - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Intracellular amyloid β (Aβ) injection suppresses the large-conductance calcium-dependent
potassium (BK) channel in cortical pyramidal cells from wild-type (WT) mice. In 3xTg …
potassium (BK) channel in cortical pyramidal cells from wild-type (WT) mice. In 3xTg …