Subclinical doses of ATP-sensitive potassium channel modulators prevent alterations in memory and synaptic plasticity induced by amyloid-β

K Salgado-Puga, J Rodriguez-Colorado… - Journal of …, 2017 - content.iospress.com
In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (K
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …

The K ATP channel activator diazoxide ameliorates amyloid-β and Tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease

D Liu, M Pitta, JH Lee, B Ray, DK Lahiri… - Journal of …, 2010 - content.iospress.com
Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium
dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP …

Effects of Aβ1–42 on the Subunits of KATP Expression in Cultured Primary Rat Basal Forebrain Neurons

G Ma, Q Fu, Y Zhang, J Gao, J Jiang, A Bi, K Liu… - Neurochemical …, 2008 - Springer
ATP-sensitive potassium channels (K ATP) play a crucial role in coupling metabolic energy
to the membrane potential of cells, thereby functioning as cellular “metabolic sensors.” …

Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease

L Wang, H Kang, Y Li, Y Shui, R Yamamoto, T Sugai… - …, 2015 - Elsevier
We previously showed that activity of the large conductance calcium-activated potassium
(Big-K; BK) channels is suppressed in 3xTg Alzheimer disease (AD) model mice. However …

Inhibition of PKA attenuates memory deficits induced by β-amyloid (1–42), and decreases oxidative stress and NF-κB transcription factors

B Eftekharzadeh, M Ramin, F Khodagholi… - Behavioural brain …, 2012 - Elsevier
Alzheimer's disease (AD), the most relevant cause of dementia in elderly, is characterized by
amyloid β (Aβ) containing plaques and neurofibrillatory tangles, synaptic and neuronal loss …

Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying …

I Sánchez‐Rodríguez, S Djebari… - Journal of …, 2020 - Wiley Online Library
Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides+ thought to be
responsible for learning and memory impairments in Alzheimer's disease (AD) early stage …

Diazoxide Reverses the Enhanced Expression of KATP Subunits in Cholinergic Neurons Caused by Exposure to Aβ1-42

G Ma, J Gao, Q Fu, L Jiang, R Wang, Y Zhang… - Neurochemical …, 2009 - Springer
The ATP-sensitive potassium channel (K ATP) play a crucial role in coupling metabolic
energy to the cell membrane potential, β-amyloid peptide (Aβ) neurotoxicity has been …

ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases

J Lv, X Xiao, M Bi, T Tang, D Kong, M Diao… - Ageing Research …, 2022 - Elsevier
ATP-sensitive potassium channels (K ATP channels), a group of vital channels that link the
electrical activity of the cell membrane with cell metabolism, were discovered on the …

ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression-and anxiety-related symptoms in a rat model of Alzheimer's …

MH Esmaeili, B Bahari, AA Salari - Brain research bulletin, 2018 - Elsevier
Affective disorders including depression and anxiety are among the most prevalent
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …

[HTML][HTML] Amyloid β and amyloid precursor protein synergistically suppress large-conductance calcium-activated potassium channel in cortical neurons

K Yamamoto, R Yamamoto, N Kato - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Intracellular amyloid β (Aβ) injection suppresses the large-conductance calcium-dependent
potassium (BK) channel in cortical pyramidal cells from wild-type (WT) mice. In 3xTg …