Purpose: To demonstrate that a mathematical model can be used to quantitatively
understand tumor cellular dynamics during a course of radiotherapy and to predict the …

A tumour control probability computational model for fractionated radiotherapy was
developed, with the goal of incorporating the fundamental interplay between hypoxia and …

Background. Conventionally fractionated radiotherapy (CFRT) has proven ineffective in
treating non-small cell lung cancer while more promising results have been obtained with …

PURPOSE: To assess how fraction size impacts lung radiation toxicity and therapeutic ratio
in treatment of lung cancers. METHODS AND MATERIALS: The relative damaged volume …

Background Standard radiobiology theory of radiation response assumes a uniform innate
radiosensitivity of tumors. However, experimental data show that there is significant …

Current protocols for delivering radiotherapy are based primarily on tumour stage and nodal
and metastases status, even though it is well known that tumours and their …

Purpose Local failure rates after radiation therapy (RT) for locally advanced non–small-cell
lung cancer (NSCLC) remain high. Consequently, RT dose intensification strategies …

Radiotherapy uses high doses of energy to eradicate cancer cells and control tumors.
Various treatment schedules have been developed and tried in clinical trials, yet significant …

Purpose: To model the influence of hypoxic radioprotection in fractionated treatments over a
range of fraction sizes. To determine whether there is a “therapeutic window” of dose per …

PURPOSE: Local tumor control and outcome remain poor in patients with advanced non-
small-cell lung cancer (NSCLC) treated by external beam radiotherapy. We investigated the …