Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death
worldwide. However, targeted therapies are still at their beginning for the treatment of this …

Liver-specific β-catenin knockout (β-Catenin-LKO) mice have revealed an essential role of β-
catenin in metabolic zonation where it regulates pericentral gene expression and in initiating …

Canonical Wnt signalling, governed by its effector β‐catenin, is known for a long time as
playing an important role in development, tissue homeostasis, and cancer. In the liver, it was …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide.
However, there is little known about targeted therapeutics for the treatment of this …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies
and one of the fastest-growing causes of cancer-related mortality in the United States. The …

Liver fibrosis is the pathological process of excessive extracellular matrix deposition after
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …

Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …