[HTML][HTML] Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients

KL Ormerod, NM George, JA Fraser, C Wainwright… - PeerJ, 2015 - peerj.com
The genetic disorder cystic fibrosis is a life-limiting condition affecting∼ 70,000 people
worldwide. Targeted, early, treatment of the dominant infecting species, Pseudomonas …

Genomic and functional characterization of longitudinal Pseudomonas aeruginosa isolates from young patients with cystic fibrosis

CE Chandler, CE Hofstaedter, TH Hazen… - Microbiology …, 2023 - Am Soc Microbiol
Individuals with cystic fibrosis (CF) suffer from frequent and recurring microbial airway
infections. The Gram-negative bacterium Pseudomonas aeruginosa is one of the most …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

RL Marvig, D Dolce, LM Sommer, B Petersen, O Ciofu… - BMC microbiology, 2015 - Springer
Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …

Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa

JR Dettman, R Kassen - Molecular biology and evolution, 2021 - academic.oup.com
The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …

Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection

SJT Wardell, J Gauthier, LW Martin… - Microbial …, 2021 - microbiologyresearch.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung

J Diaz Caballero, ST Clark, B Coburn, Y Zhang… - MBio, 2015 - Am Soc Microbiol
Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs

J Klockgether, N Cramer, S Fischer… - American journal of …, 2018 - atsjournals.org
Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection

SE Darch, A McNally, F Harrison, J Corander… - Scientific reports, 2015 - nature.com
Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …

Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny

L Stewart, A Ford, V Sangal, J Jeukens… - Pathogens and …, 2014 - academic.oup.com
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen particularly
associated with the inherited disease cystic fibrosis (CF). Pseudomonas aeruginosa is well …