Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Toll receptors: an expanding role in our understanding of human disease

JM Schuster, PS Nelson - Journal of Leukocyte Biology, 2000 - academic.oup.com
Toll receptor proteins in Drosophila are involved in establishing the dorsal-ventral axis in
embryogenesis as well as participating in the innate immune response to invading …

Immunobiology of Toll‐like receptors: emerging trends

S Pandey, DK Agrawal - Immunology and Cell Biology, 2006 - Wiley Online Library
Toll‐like receptors (TLR), a family of evolutionarily conserved pathogen recognition
receptors, play pivotal role as primary sensors of invading pathogens. TLR identify …

Toll‐like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes

M Muzio, N Polentarutti, D Bosisio… - Journal of leukocyte …, 2000 - Wiley Online Library
Toll is a Drosophila gene essential for ontogenesis and antimicrobial resistance. Several
hortologues of Toll have been identified and cloned in vertebrates, namely Toll‐like …

[HTML][HTML] A comparative review of toll-like receptor 4 expression and functionality in different animal species

C Vaure, Y Liu - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptors (TLRs) belong to the pattern recognition receptor (PRR) family, a key
component of the innate immune system. TLRs detect invading pathogens and initiate an …

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer

LAJ O'Neill, CE Bryant, SL Doyle - Pharmacological reviews, 2009 - ASPET
Since first being described in the fruit fly Drosophila melanogaster, Toll-like receptors (TLRs)
have proven to be of great interest to immunologists and investigators interested in the …

RETRACTED: Expression and function of Toll-like receptor on T cells

D Xu, M Komai-Koma, FY Liew - Cellular Immunology, 2005 - Elsevier
Toll is the founder of a group of pattern recognition receptors, which play a critical role in the
innate immunity in Drosophila. At least 13 distinct Toll-like receptors (TLRs), recognising …

Critical roles of Toll-like receptors in host defense

T Kaisho, S Akira - Critical Reviews™ in Immunology, 2000 - dl.begellhouse.com
Drosophila Toll is involved not only in dorsoventral patterning of embryos but also in
immune responses to microbial infection. Several Toll-like receptors (TLRs) have also been …

Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways

A Roy, M Srivastava, U Saqib, D Liu, SM Faisal… - International …, 2016 - Elsevier
Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

Toll-like receptors as targets for immune disorders

B Keogh, AE Parker - Trends in Pharmacological Sciences, 2011 - cell.com
Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding
of the molecular basis for innate immunity has increased significantly. The TLR family and …