One strategy for a functional cure of HIV-1 is “block and lock”, which seeks to permanently
suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter …

Elucidating the mechanism of human immunodeficiency virus, type 1 (HIV-1) provirus
transcriptional silencing in latently infected cells is crucial for understanding the …

Latent HIV proviruses are silenced as the result of deacetylation and methylation of histones
located at the viral long terminal repeat (LTR). Inhibition of histone deacetylases (HDACs) …

Histone methyltransferase inhibitors (HMTis) and histone deacetylase inhibitors (HDACis)
are reported to synergistically induce the expression of latent human immunodeficiency …

Epigenetic modifications are thought to be important for gene expression changes during
HIV-1 transcription and replication. The removal of histone H3 lysine27 (H3K27) …

Understanding the mechanisms that drive HIV expression and latency is a key goal for
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …

We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2)
is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the …

Understanding the mechanism of HIV-1 latency is crucial to eradication of the viral reservoir
in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like …

Objective: Reactivation of HIV-1 expression in persistent reservoirs together with an efficient
HAART has been proposed as an adjuvant therapy aimed at reaching a functional cure for …

Background The recent discovery of the role of m6A methylation in the regulation of HIV-1
replication unveiled a novel layer of regulation for HIV gene expression. This …