The internal N 6-methyladenosine (m6A) methylation of eukaryotic nuclear RNA controls
post-transcriptional gene expression, which is regulated by methyltransferases (writers) …

Background Integration of human immunodeficiency virus type 1 (HIV-1) into the host
genome causes global disruption of the chromatin environment. The abundance level of …

Arising from L. Kruidenier et al. Nature488, 404–408 (2012); doi: 10.1038/nature11262 The
recent publication of the first highly potent and specific inhibitor GSK-J1/J4 of the …

The Tat protein of HIV-1 plays an essential role in HIV gene expression by promoting
efficient elongation of viral transcripts. Posttranslational modifications of Tat fine-tune …

Abstract N6-methyladenosine (m6A) methylation of human immunodeficiency virus type 1
(HIV-1) RNA regulates viral replication, and the m6A of host RNA is affected by HIV-1 …

ABSTRACT Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification
that is best known for its role in constitutive heterochromatin formation and the repression of …

DNA methylation and histone modifications are two major epigenetic events regulating gene
expression and chromatin structure, and their alterations are linked to human …

HIV‐1 gene expression is the major determinant regulating the rate of virus replication and,
consequently, AIDS progression. Following primary infection, most infected cells produce …

Mammalian genomes are replete with retrotransposable elements, including endogenous
retroviruses. DNA methyltransferase 3-like (DNMT3L) is an epigenetic regulator expressed …

Covalent addition of a methyl group to adenosine N 6 (m 6 A) is an evolutionarily conserved
and common RNA modification that is thought to modulate several aspects of RNA …