In order to exploit the transdermal route for systemic delivery of a wide range of drug
molecules, including peptide/protein molecules and genetic material, a means of disrupting …

Many promising therapeutic agents are limited by their inability to reach the systemic
circulation, due to the excellent barrier properties of biological membranes, such as the …

The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …

Transdermal delivery offers an attractive, noninvasive administration route but it is limited by
the skin's barrier to penetration. Minimally invasive techniques, such as the use of …

Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin
painlessly, noninvasively, and safety. In the past several decades, various types of MNs …

The success of transdermal drug delivery has been severely limited by the inability of most
drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale …

Improving drug permeability in the skin is one of the most important issues for designing new
methods of transdermal drug delivery. Consequently, many techniques have been proposed …

Transdermal route has been explored for various agents due to its advantage of bypassing
the first pass effect and sustained release of drug. Due to strong barrier properties of the …

Transdermal delivery has become a popular route of drug delivery in recent years. However,
permeation of drugs through skin is limited to small lipophilic molecules. Microneedle …

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery
methods of oral administration and injection. However, the stratum corneum acts as a barrier …