Female oxytocin-deficient mice display enhanced anxiety-related behavior

RC Mantella, RR Vollmer, X Li, JA Amico - Endocrinology, 2003 - academic.oup.com
Previous studies have suggested that oxytocin (OT) may be anxiolytic in female laboratory
rats and mice. The elevated plus-maze was used to compare anxiety-related behaviors of …

From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders

A Romano, B Tempesta… - Frontiers in …, 2016 - frontiersin.org
Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and
supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a …

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

H Nishimura, M Yoshimura, M Shimizu… - Communications …, 2022 - nature.com
Oxytocin is involved in pain transmission, although the detailed mechanism is not fully
understood. Here, we generate a transgenic rat line that expresses human muscarinic …

Sex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin

MQ Steinman, N Duque-Wilckens, GD Greenberg… - Biological …, 2016 - Elsevier
Background Oxytocin (OT) is considered to be a stress-buffering hormone, dampening the
physiologic effects of stress. However, OT can also be anxiogenic. We examined acute and …

Bridging the gap between rodents and humans: the role of non‐human primates in oxytocin research

PT Putnam, LJ Young… - American journal of …, 2018 - Wiley Online Library
Oxytocin (OT), a neuropeptide that acts in the brain as a neuromodulator, has been long
known to shape maternal physiology and behavior in mammals, however its role in …

The acute effects of intranasal oxytocin administration on endocrine and sexual function in males

A Burri, M Heinrichs, M Schedlowski… - …, 2008 - Elsevier
The role of the neuropeptide oxytocin (OT) ranges from the modulation of neuroendocrine
physiological effects to the establishment of complex social and bonding behaviours …

Fear-enhancing effects of septal oxytocin receptors

YF Guzmán, NC Tronson, V Jovasevic, K Sato… - Nature …, 2013 - nature.com
The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic,
prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans …

Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice

JA Amico, RR Vollmer, JR Karam, PR Lee, X Li… - Pharmacology …, 2004 - Elsevier
Experiments were conducted to determine if the chronic absence of the neurotransmitter
oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of …

Long-acting and selective oxytocin peptide analogs show antidiabetic and antiobesity effects in male mice

B Snider, A Geiser, X Yu, EC Beebe… - Journal of the …, 2019 - academic.oup.com
Oxytocin (OXT) has been shown to suppress appetite, induce weight loss, and improve
glycemic control and lipid metabolism in several species, including humans, monkeys, and …

Effects of intranasal oxytocin on steroid hormones in men and women

MM Wirth, AE Gaffey, BS Martinez - Neuropsychobiology, 2015 - karger.com
Background: Recent interest in the social and cognitive effects of intranasal oxytocin
prompts a need for understanding its physiological effects in humans. Few studies have …