Background: The placenta acts not only as a conduit of nutrient and waste exchange
between mother and developing fetus but also functions as a regulator of the intrauterine …

Emerging evidences indicate that placenta plays a critical role in gestational diabetes
mellitus (GDM). DNA methylation could be associated with altered placental development …

Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Objective: DNA methylation is an important epigenetic regulator of gene transcription, and is
involved in many diseases, which has been researched recently. In this study, we aimed to …

The development of preeclampsia (PE) seriously affects the health of the mother and the
child, but the precise pathogenesis of PE remains elusive. The placenta is considered to …

Introduction Preeclampsia (PE) is one of the leading causes of maternal mortality and
morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has …

Background The human placenta facilitates the exchange of nutrients, gas and waste
between the fetal and maternal circulations. It also protects the fetus from the maternal …

Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy
and proper maternal-fetal exchanges through the placenta and are very sensitive to …

Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

Background Preeclampsia (PE) is an obstetric disorder with significant morbidities for both
the mother and fetus possibly caused by a failure of the placental trophoblast invasion …