[HTML][HTML] cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …
Innate immunosensing of DNA in cellular senescence
S Glück, A Ablasser - Current opinion in immunology, 2019 - Elsevier
Highlights•Cellular senescence is a key cellular stress response pathway.•Senescent cells
produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING …
produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING …
[HTML][HTML] The role of cGAS-STING in age-related diseases from mechanisms to therapies
With aging, the incidence of age-related diseases increases. Hence, age-related diseases
are inevitable. However, the mechanisms by which aging leads to the onset and progression …
are inevitable. However, the mechanisms by which aging leads to the onset and progression …
cGAS/STING: novel perspectives of the classic pathway
M Gao, Y He, H Tang, X Chen, S Liu, Y Tao - Molecular Biomedicine, 2020 - Springer
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …
Attenuation of cGAS/STING activity during mitosis
BL Uhlorn, ER Gamez, S Li… - Life science …, 2020 - life-science-alliance.org
The innate immune system recognizes cytosolic DNA associated with microbial infections
and cellular stress via the cGAS/STING pathway, leading to activation of phospho-IRF3 and …
and cellular stress via the cGAS/STING pathway, leading to activation of phospho-IRF3 and …
Molecular mechanisms and cellular functions of cGAS–STING signalling
KP Hopfner, V Hornung - Nature reviews Molecular cell biology, 2020 - nature.com
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Cellular senescence is triggered by various distinct stresses and characterized by a
permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors …
permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors …
[HTML][HTML] The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degeneration
The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …
Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
N Ohtani - The journal of biochemistry, 2019 - academic.oup.com
Cellular senescence is an irreversible form of cell cycle arrest that can be induced by
persistent DNA damage, and is well known to function as an important tumour suppression …
persistent DNA damage, and is well known to function as an important tumour suppression …