Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Double stranded DNA (dsDNA) is known to act as a damage‐associated molecular pattern
(DAMP) that stimulates the body's innate immune response. In general, cyclic GMP-AMP …

Cytoplasmic microbial and host aberrant DNAs act as danger signals and trigger host
immune responses. Upon recognition, the cytosolic DNA sensor cyclic GMP–AMP synthase …

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

Cyclic GMP-AMP synthase (cGAS) recognizes double-stranded DNA (dsDNA) derived from
invading pathogens and induces an interferon response via activation of the key …

Within the cytoplasm of mammalian cells is a protein called cyclic GMP‐AMP synthase
(cGAS), which acts to defend against infection and other threats to the host. cGAS operates …

Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and
cellular components. Advancing age closely associates with elevated markers of innate …

Sterile inflammation characterized by unresolved chronic inflammation is well established to
promote the progression of multiple autoimmune diseases, metabolic disorders …

Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor
effects of several therapies, including radiation and chemotherapeutic drugs. Senescence …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …