The aging process is associated with a remodeling of the immune system involving chronic
low-grade inflammation and a gradual decline in the function of the immune system. These …

The host innate immunity offers the first line of defense against infection. However, recent
evidence shows that the host innate immunity is also critical in sensing the presence of …

BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …

The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …

Ageing is the major risk factor for cancer development. Hallmark of the ageing process is
represented by inflammaging, which is a chronic and systemic low-grade inflammatory …

Abstract Cyclic GMP-AMP synthase (cGAS) is a cytosolic nucleic acid sensor that can bind to
dsDNA. It maintains an autoinhibited state in the absence of cytosolic dsDNA, while when …

Stimulator of Interferon Gene (STING) is a critical signaling linker protein that plays a crucial
role in the intrinsic immune response, particularly in the cytoplasmic DNA-mediated immune …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Background: Aging is a multifactorial process driven by several conditions. Among them,
inflamm-aging is characterized by chronic low-grade inflammation driving aging-related …

The systemic dysregulation of adaptive and innate immunity have been identified as major
hallmark of systemic lupus erythematosus (SLE) pathogenesis that predominantly affects …