Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active,
as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the
mammalian innate immune system that is recognized as a main cytosolic sensor of …

DNA sensing is a pivotal component of the innate immune system that is responsible for
detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the …

Cytosolic nucleic acid sensors contribute to the initiation of innate immune responses by
playing a critical role in the detection of pathogens and endogenous nucleic acids. The …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS–STING) signaling
pathway, as vital component of innate immune system, acts a vital role in distinguishing …

Cyclic GMP–AMP synthase (cGAS) is the synthase that generates the second messenger
cyclic GMP–AMP (cGAMP) upon DNA binding. cGAS was first discovered as the cytosolic …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Early detection of infectious nucleic acids released from invading pathogens by the innate
immune system is critical for immune defense. Detection of these nucleic acids by host …