The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …

Ageing is a very complex process, the result of the dysregulation of multiple systems
interacting in many ways. A prominent change occurring with ageing is related to the …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …

The cGAS–STING signaling axis can be activated by cytosolic DNA, including both non-self
DNA and self DNA. This axis is used by the innate immune system to monitor invading …

Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In
mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the …

Nowadays, new advances in society and health have brought an increased life expectancy.
However, at the same time, aging comes with complications that impact the development of …

The term cellular senescence was used in 1961 for the first time by Hayflick and Moorhead
[1], to define the mechanism determining the irreversible loss of the proliferative activity of …

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is
a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous …

Highlights•There is a general signal transduction alteration in immune cells with human
aging.•The most important changes occur at the proximal signaling of TCR.•Not only the …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …