Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that initiates innate immune
responses. DNA-bound cGAS produces cyclic GMP-AMP (cGAMP), which activates …

Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under
investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its …

With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …

Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …

Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now
recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

Cellular senescence is historically regarded as a tumor suppression mechanism to prevent
damaged cells from aberrant proliferation in benign and premalignant tumors. However …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …