The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Abstract Edited by Jiarui Wu Cytosolic nucleic acid sensors are critical for sensing nucleic
acids and initiating innate immunity during microbial infections and/or cell death. Over the …

During aging, general cellular processes, including autophagic clearance and
immunological responses become compromised; therefore, identifying compounds that …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

Recent studies have shown that genomic instability in tumor cells leads to activation of
inflammatory signaling through the cGAS/STING pathway. In this review, we describe …

'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging. The
conceptualization of inflammaging, resulting from the convergence of studies on the …

Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic
inflammatory state termed inflammaging. The significance of these phenomena is …

Recent studies have illustrated the functional significance of DNA recognition in the
activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP …

Ageing has pronounced effects on the immune system, including on innate immune cells.
Whilst most studies suggest that total numbers of different innate immune cell populations do …