Cyclic GMP-AMP synthase (cGAS) is a predominant and ubiquitously expressed cytosolic
onfirmedDNA sensor that activates innate immune responses by producing a second …

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Systematic understanding of immune aging on a whole-body scale is currently lacking. We
characterized age-associated alterations in immune cells across multiple mouse organs …

Tumor suppression by TP53 involves cell-autonomous and non-cell-autonomous
mechanisms. TP53 can suppress tumor growth by modulating immune system functions; …

Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to
initiate innate immune responses during microbial infections and/or cell death. Several …

The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway is an
essential component of the innate immune system and is central to the identification of …

The intestinal mucosa is constantly exposed to commensal microbes, opportunistic
pathogens, toxins, luminal components and other environmental stimuli. The intestinal …

The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic
acids represent a major class of pathogen signatures that can trigger robust immune …

Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …

Ageing is the biggest risk factor for the development of multiple chronic diseases as well as
increased infection susceptibility and severity of diseases such as influenza and COVID-19 …