The destruction of the intestinal barrier is likely to cause an increase in intestinal
permeability and cause pathological damage. Numerous studies have demonstrated that …

Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …

Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where
macrophages are recruited and polarized locally into M1 type to drive further inflammation …

Dysregulated mucosal immune responses and colonic fibrosis impose two formidable
challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently …

Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …

Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in
inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis and …

Oxidative stress and abnormally high levels of reactive oxygen species (ROS) play an
essential role in the pathogenesis and progression of inflammatory bowel disease (IBD) …

Oral gene therapy has emerged as a potential optimal treatment for ulcerative colitis (UC).
Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon …

Purpose Conventional oral formulations for inflammatory bowel disease (IBD) treatment are
less than satisfactory, due to the poor controllability of drug release and lack of specificity to …

Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent
inflammatory immune response and is often accompanied by excessive reactive oxygen …