Recently, we have shown that compared to controls, long-lived familial nonagenarians
(mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …

Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are
involved in the control of ageing and longevity in model organisms. Based on these studies …

Longevity in yeast, nematodes, fruit flies and mice is affected by mutations in the insulin/IGF-
1 or homologous pathways. Studies on long-living people revealed some associations …

The insulin/IGF1 signaling pathways affect lifespan in several model organisms, including
worms, flies and mice. To investigate whether common genetic variation in this pathway …

Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with
longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …