Muscular dystrophies are a group of diseases that primarily affect skeletal muscle and are
characterized by progressive muscle wasting and weakness. Although these diseases have …

Duchenne muscular dystrophy was described in the medical literature in the early 1850s but
the molecular basis of the disease was not determined until the late 1980s. The cloning of …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is
associated with a large oligomeric complex of sarcolemmal glycoproteins, including …

Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is a
cytoskeletal protein tightly associated with a large oligomeric complex of sarcolemmal …

Duchenne muscular dystrophy is the most prevalent and severe form of human muscular
dystrophy. Investigations into the molecular basis for Duchenne muscular dystrophy were …

Dystrophin plays an important role in skeletal muscle by linking the cytoskeleton and the
extracellular matrix. The amino terminus of dystrophin binds to actin and possibly other …

Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is a major
component of the subsarcolemmal cytoskeleton and exists in a large oligomeric complex …

Duchenne muscular dystrophy was a well‐established medical and genetic enigma by the
1970s. Why was the new mutation rate so high in all world populations? Why were affected …

Defects in the gene for the muscle protein dystrophin cause many cases of muscular
dystrophy. Worton discusses three new papers, one in this issue of Science (Noguchi et al …