Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …

Background: The process of bone remodelling is disturbed in the development of
osteoporosis. Objective: To investigate if proteins in osteoporotic bone are modified by …

Non-enzymatic glycation of proteins, such as collagen, results in the formation of advanced
glycation endproducts (AGE). Advanced glycation endproducts result in pathologic stiffening …

AGEs accumulation in the skin affects extracellular matrix (ECM) turnover and triggers
diabetes associated skin conditions and accelerated skin aging. The receptor of AGEs …

Osteoarthritis (OA) is significantly associated with diabetes, but how hyperglycemia induces
or aggravates OA has not been shown. The synovium plays a critical role in cartilage …

Background—The products of nonenzymatic glycation and oxidation of proteins, the
advanced glycation end products (AGEs), form under diverse circumstances such as aging …

Advanced glycation end products (AGEs) have been proposed as the pathological
mechanisms underlying diabetic chronic complications. They may also play a role in the …

It is well accepted that aging is an important contributing factor to the development of
osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may …

Glycation and the accumulation of advanced glycation end products (AGEs) are known to
occur during normal aging but also in the progression of several diseases, such as diabetes …

Osteoarthritis (OA) is a major age-related disease, which may be caused by the
accumulation of advanced glycation end-products (AGEs). Excessive degradation of type II …