Leukocyte infiltrates into or around tumor cell nests are found in the context of
protumorigenic inflammation and anticancer immunosurveillance. Hence, the detailed …

In the recent years, breakthrough advances in the characterization of the tumor-infiltrating
immune cells and in the understanding of their influence on tumor invasion and metastasis …

Abstract The American Joint Committee on Cancer/Union Internationale Contre le Cancer
(AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor features …

Solid tumors are constituted of a variety of cellular components, including bona fide
malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor …

Numerous analyses of large patient cohorts identified specific patterns of immune activation
associated with patient survival. We established these as the immune contexture …

Highlights•The immune contexture is a powerful tool to predict patient's clinical
outcome.•Chronic inflammation can foster cancer development and tumour growth.•An …

The interplay between tumors and their immunologic microenvironment is complex and
difficult to decipher, but its understanding is of seminal importance for the development of …

Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Until now, the anatomic extent of tumor (TNM classification) has been, by far, the most
important factor to predict the prognosis of colorectal cancer patients. However, in recent …

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels,
cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating …