The worrisome increase in Gram-negative bacteria with borderline susceptibility to
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …

Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Population pharmacokinetic analyses can be applied to predict optimized dosages for
individual patients. The aim of this study was to compare the prediction performance of the …

Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …

Background: Pharmacokinetics of meropenem differ widely in the critically ill population. It is
imperative to maintain meropenem concentrations above the inhibitory concentrations for …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Introduction: optimal treatment of Gram-negative infections in critically ill patients is
challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility …

The pharmacokinetics and pharmacodynamics of meropenem were investigated in 14
critically ill patients with sepsis. Patients with creatinine clearance (CrCl) higher than 50 …

Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …