We previously reported a kindred with three cases of dementia, in which the proband
exhibited features typical of frontotemporal dementia and parkinsonism (FTDP). An arginine …

Mutations in the progranulin gene (PGRN), on chromosome 17q21, have recently been
identified as a major cause of familial frontotemporal dementia (FTD). These cases have a …

Mutations in progranulin (PGRN) are associated with frontotemporal dementia with or
without parkinsonism. We describe the prominent phenotypic variability within and among …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Objective To characterize a kindred with a familial neurodegenerative disorder associated
with a mutation in progranulin (PGRN), with emphasis on the unique clinical features in this …

The most common pathology in frontotemporal dementia (FTD) is tau-negative, ubiquitin-
immunoreactive (ub-ir) neuronal inclusions (FTLD-U). Recently, we identified mutations in …

Mutations in the progranulin (GRN) gene have recently been reported as a cause of the
frontotemporal dementia (FTD) syndrome. We performed a clinical, neuropathological and …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Null mutations in the progranulin gene (PGRN) were recently reported to cause tau-negative
frontotemporal dementia linked to chromosome 17. We assessed the genetic contribution of …

Background Progranulin gene (PGRN) haploinsufficiency was recently associated with
ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU …