Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …

Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the
first step in T-cell mediated immune response. To understand the structural principles …

The class I major histocompatibility complex (MHC) is capable of binding peptides derived
from intracellular proteins and displaying them at the cell surface. The recognition of these …

The recognition of peptides bound to class I major histocompatibility complex (MHC-I)
receptors by T-cell receptors (TCRs) is a determinant of triggering the adaptive immune …

The Major Histocompatibility Complex (MHC) constitutes an important part of the human
immune system. During infection, pathogenic proteins are processed into peptide fragments …

Computation methods that predict the binding of peptides to MHC-I are important tools for
screening and identifying immunogenic antigens and have the potential to accelerate …

Since determining the crystallographic structure of all peptide‐MHC complexes is infeasible,
an accurate prediction of the conformation is a critical computational problem. These models …

Predicting the binding affinity of peptides able to interact with major histocompatibility
complex (MHC) molecules is a priority for researchers working in the identification of novel …

Abstract Development of a computational prediction method based on molecular modeling,
global optimization, and implicit solvation has produced accurate structure and relative …

The presentation of potentially pathogenic peptides by major histocompatibility complex
(MHC) molecules is one of the most important processes in adaptive immune defense …