Sepsis is a syndrome which is defined as a dysregulated host response to infection leading
to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Advances in pathogenesis and management of sepsis : Current Opinion in Infectious Diseases
Advances in pathogenesis and management of sepsis : Current Opinion in Infectious Diseases …

Sepsis secondary to bacterial infection remains a significant cause of morbidity and mortality
globally. Recent decades have seen the evolution of international collaborations to improve …

The diseases of critical illness are rooted in the response of the host to clinical interventions
that have thwarted imminent death. Sepsis—the clinical syndrome that embodies the …

D espite recent improvements in intensive care monitoring, diagnostic techniques, and
therapies, sepsis remains common among the critically ill. Moreover, related mortality rates …

Pathophysiologic basis of sepsis: Considerations for future... : Critical Care Medicine
Pathophysiologic basis of sepsis: Considerations for future strategies of intervention : Critical …

Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host
response to an infection, remains a major challenge for clinicians and trialists. Despite …

Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …