Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …

Intrinsically disordered proteins (IDPs) and regions (IDRs) form a large part of the eukaryotic
proteome. Contrary to the structure–function paradigm, the disordered proteins perform a …

Highlights•Intrinscially disordered proteins (IDPs) are abundant and involved in many
diseases.•Advances and challenges in drug design targeting IDPs are discussed.•Known …

Intrinsically disordered proteins (IDPs) are over-represented in major disease pathways and
have attracted significant interest in understanding if and how they may be targeted using …

Introduction: There is a natural abundance of intrinsically disordered proteins or intrinsically
disordered protein regions (IDPs or IDPRs), that is, biologically active proteins/regions …

Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently
emerged as major therapeutic targets for various diseases. Unlike traditional proteins that …

Various studies have revealed that important biological functions of many proteins do not
require stable well‐defined structure in solution, with many functions originating from the …

Intrinsically disordered proteins (IDPs) were found to be widely associated with human
diseases and may serve as potential drug design targets. However, drug design targeting …

Intrinsically disordered proteins (IDPs), polypeptide chains that do not fold into a
homogeneous three-dimensional (3D) structure, are overrepresented in major human …

Introduction: Intrinsically disordered proteins (IDPs) and intrinsically disordered protein
regions (IDPRs) have gained wide recognition over the past decade due to their versatile …