2′-Fucosyllactose Promotes the Production of Short-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated Mice by Regulating Gut …

Q Chen, Q Yin, Q Xie, C Jiang, L Zhou… - Journal of Agricultural …, 2022 - ACS Publications
As a natural prebiotic in human milk, 2′-fucosyllactose (2′-FL) is actively used in infant
formula (IF). However, the 2′-FL influence on the improvement of gut microbiota and the …

The protective effect of 2'-Fucosyllactose on LPS-induced colitis suckling mice by ameliorating intestinal inflammation and modulating gut microbiota

H Lv, Q Li, Z Zhou, H Fang, Q Chen, Y Shuai - Food Bioscience, 2023 - Elsevier
Fucosyllactose (2′-FL), the main component of human milk oligosaccharides (HMOs), has
been shown to prevent intestinal diseases and its underlying mechanism remains unclear …

2'-Fucosyllactose (2'-FL) changes infants gut microbiota composition and their metabolism in a host-free human colonic model

S Zhang, L Chen, M Hu, J Zhu - Food Research International, 2023 - Elsevier
Background Breast milk is critical for neonates, providing the necessary energy, nutrients,
and bioactive compounds for growth and development. Research indicated that human milk …

[HTML][HTML] The Protective Effects of 2'-Fucosyllactose Against E. Coli O157 Infection Are Mediated by the Regulation of Gut Microbiota and the Inhibition of Pathogen …

Y Wang, Y Zou, J Wang, H Ma, B Zhang, S Wang - Nutrients, 2020 - mdpi.com
As the richest component in human milk oligosaccharides (HMOs), 2'-fucosyllactose (2'-FL)
can reduce the colonization of harmful microbiota in vivo, thus lowering the risk of infection; …

2′-Fucosyllactose alleviates OVA-induced food allergy in mice by ameliorating intestinal microecology and regulating the imbalance of Th2/Th1 proportion

R Kou, J Wang, A Li, Y Wang, D Fan, B Zhang, W Fu… - Food & Function, 2023 - pubs.rsc.org
Food allergy (FA) has become a prominent problem in public health. 2′-Fucosyllactose
(2′-FL) was reported to alleviate FA symptoms; however, the regulatory mechanism is still …

[HTML][HTML] The prebiotics 2′-fucosyllactose prevent high-fat diet induced obesity via the promotion of thermogenesis and modulation of gut microbiota

T Li, X Lin, X Mao, S Chen, Z Feng, Y Fu, P Zhao… - Journal of Functional …, 2024 - Elsevier
fucosyllactose (2′-FL) is one of the most prevalent milk oligosaccharides. In this study, the
anti-obesity effect of 2′-FL was explored in high-fat diet (HFD)-fed mice. Results showed …

[HTML][HTML] Effects of Bifidobacterium with the Ability of 2′-Fucosyllactose Utilization on Intestinal Microecology of Mice

B Mao, Z He, Y Chen, C Stanton, RP Ross, J Zhao… - Nutrients, 2022 - mdpi.com
In breast milk, 2′-Fucosyllactose (2′ FL) is the most abundant breast milk oligosaccharide
and can selectively promote the proliferation of bifidobacteria. This study aimed to explore …

[HTML][HTML] 2′-fucosyllactose supplementation improves gut-brain signaling and diet-induced obese phenotype and changes the gut microbiota in high fat-fed mice

S Lee, M Goodson, W Vang, K Kalanetra, D Barile… - Nutrients, 2020 - mdpi.com
Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety
signaling, which may be due in part to gut microbial dysbiosis. Manipulations of the gut …

A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism

KM Schalich, MA Buendia, H Kaur, YA Choksi… - Mbio, 2024 - Am Soc Microbiol
Observational evidence suggests that human milk oligosaccharides (HMOs) promote the
growth of commensal bacteria in early life and adulthood. However, the mechanisms by …

[HTML][HTML] 2′-fucosyllactose ameliorates inflammatory bowel disease by modulating gut microbiota and promoting MUC2 expression

Q Yao, L Fan, N Zheng, C Blecker, V Delcenserie… - Frontiers in …, 2022 - frontiersin.org
Gut microbiota dysbiosis, together with goblet cells dysfunction has been observed in
ulcerative colitis cases. This study aims to evaluate the potential of 2′-fucosyllactose (2 …