The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials
When little or no data directly comparing two treatments are available, investigators often
rely on indirect comparisons from studies testing the treatments against a control or placebo …
rely on indirect comparisons from studies testing the treatments against a control or placebo …
[引用][C] Considerations for the meta-analysis of randomized clinical trials: summary of a panel discussion
JP Boissel, J Blanchard, E Panak, JC Peyrieux… - Controlled clinical …, 1989 - Elsevier
In therapeutic research meta-analysis is most commonly used to determine more precisely
the beneficial and/or harmful effects of a given treatment from a collection of randomized …
the beneficial and/or harmful effects of a given treatment from a collection of randomized …
Strengths and limitations of meta-analysis: larger studies may be more reliable
Meta-analysis of randomized controlled trials combines information from independent
studies that address a similar question to provide more reliable estimates of treatment …
studies that address a similar question to provide more reliable estimates of treatment …
Issues in comparisons between meta-analyses and large trials
Context.—The extent of concordance between meta-analyses and large trials on the same
topic has been investigated with different protocols. Inconsistent conclusions created …
topic has been investigated with different protocols. Inconsistent conclusions created …
[HTML][HTML] Discrepancies between meta-analyses and subsequent large randomized, controlled trials
J LeLorier, G Gregoire, A Benhaddad… - … England Journal of …, 1997 - Mass Medical Soc
Background Meta-analyses are now widely used to provide evidence to support clinical
strategies. However, large randomized, controlled trials are considered the gold standard in …
strategies. However, large randomized, controlled trials are considered the gold standard in …
Uses and abuses of meta-analysis
Meta-analysis, the statistical combination of results from several studies to produce a single
estimate of the effect of a treatment, continues to attract controversy. We illustrate the …
estimate of the effect of a treatment, continues to attract controversy. We illustrate the …
Meta-analysis of randomized controlled trials: a concern for standards
D Moher, I Olkin - Jama, 1995 - jamanetwork.com
Evidence-based health care is becoming increasingly popular and, at least in some settings,
is being used to assist in the creation of health care policy. 1 Meta-analyses are a key …
is being used to assist in the creation of health care policy. 1 Meta-analyses are a key …
[引用][C] Statistical methods for examining heterogeneity and combining results from several studies in meta‐analysis
This chapter contains section titled: Summary Points Meta—Analysis Formulae for Estimates
of Effect from Individual Studies Formulae for Deriving a Summary (Pooled) Estimate of the …
of Effect from Individual Studies Formulae for Deriving a Summary (Pooled) Estimate of the …
Resolving discrepancies between a meta-analysis and a subsequent large controlled trial
R DerSimonian, RJ Levine - Jama, 1999 - jamanetwork.com
ContextA recent meta-analysis found calcium supplementation to be highly effective in
preventing preeclampsia but a large National Institutes of Health trial (Calcium for …
preventing preeclampsia but a large National Institutes of Health trial (Calcium for …
Meta‐analysis of clinical trials as a scientific discipline. II: Replicate variability and comparison of studies that agree and disagree
The replicate variability of meta‐analyses of controlled clinical trials has been assessed as a
measure of scientific precision. 46 of 91 known meta‐analysis papers were divided into 20 …
measure of scientific precision. 46 of 91 known meta‐analysis papers were divided into 20 …