Background: The reduction of the nicotine content of cigarettes to nonaddicting levels is a
potential federal regulatory intervention to reduce the prevalence of cigarette smoking and …

Regulations requiring a reduction of the nicotine content in cigarettes to minimally addictive
levels could significantly reduce the public health impact of cigarette smoking. Clinical trials …

Abstract Background: The US FDA has the authority to limit the nicotine content of cigarettes;
however, there are concerns that reduced nicotine cigarettes will be smoked more intensely …

Background and Aims A broadly mandated reduction of the nicotine content (RNC) of
cigarettes has been proposed in the United States to reduce the addictiveness of cigarettes …

Background: Recent federal legislation gives the US Food and Drug Administration authority
to regulate the nicotine content of cigarettes. A nationwide strategy for progressive reduction …

Background: Mandated reduction of exposure to nicotine and other cigarette toxins has
been proposed as a possible national regulatory strategy. However, tapering using lower …

Importance The optimal temporal approach for reducing nicotine to minimally or
nonaddictive levels in all cigarettes sold in the United States has not been determined …

Abstract Background: The US FDA has the authority to reduce cigarette nicotine content if
found to benefit public health. Reduced nicotine content (RNC) cigarette use does not …

Reducing the addictiveness of cigarettes by reducing their nicotine content can potentially
have a profound impact on public health. Two different approaches to nicotine reduction …

Background: Reducing the nicotine content of cigarettes to make them non-addictive has
been widely discussed as a potential strategy for tobacco regulation. A major concern with …