Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the
application of Yamanaka factors (OSKM), but the mechanisms underlying this …

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) with
transcription factors (eg, Oct4 (O), Sox2 (S), Klf4 (K), and c-Myc (M)) greatly expands our …

Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner
with reprogramming factor binding, transcription, and chromatin states changing during …

Abstract In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally
differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent …

The success of Yamanaka factor reprogramming of somatic cells into induced pluripotent
stem cells suggests that some factor (s) must remodel the nuclei from a condensed state to a …

In 2006, the “wall came down” that limited the experimental conversion of differentiated cells
into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a …

Introduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, can successfully
reprogram somatic cells into embryonic stem (ES)-like cells. These cells, which are referred …

Reprogramming somatic cells to induced pluripotency by Yamanaka factors is usually slow
and inefficient and is thought to be a stochastic process. We identified a privileged somatic …

The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the
most remarkable discoveries in recent decades. However, several works have reported …

Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …