Human-induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells
using defined factors and provide a renewable source of autologous cells for cell therapy …

The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from
the most readily available source—peripheral blood—has the potential to expedite the …

Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …

Direct reprogramming of human somatic cells into pluripotency has broad implications in
generating patient-specific induced pluripotent stem (iPS) cells for disease modeling and …

Induced pluripotent stem (iPS) cells were created from mouse fibroblasts by induced
expression of Yamanaka factors, Oct3/4, Sox2, Klf4, and c-Myc. This technique has quickly …

Cellular reprogramming converts differentiated cells into induced pluripotent stem cells
(iPSCs). However, this process is typically very inefficient, complicating mechanistic studies …

Previous studies demonstrated that induced pluripotent stem (iPS) cells could produce
viable mice through tetraploid complementation, which was thought to be the most stringent …

Ectopic expression of specific factors such as Oct4, Sox2, and Klf4 (OSK) is sufficient to
reprogram somatic cells into induced pluripotent stem cells (iPSCs). In this study, we …

The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using
defined factors provides new tools for biomedical research. However, some iPSC clones …

Nuclear reprogramming technology was first established more than 50 years ago. It can
rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new …