Antimicrobial resistance (AMR) is fast becoming a medical crisis affecting the entire global
population. World Health Organization (WHO) statistics show that globally 0.7 million people …

Emergence of multi-drug resistant strains of Acinetobacter baumannii has caused significant
health problems and is responsible for high morbidity and mortality. Overexpression of …

Multiple drug resistance (MDR) in bacteria has increased globally in recent times. This has
reduced the efficacy of antibiotics and increasing the rate of therapeutic failure. Targeting …

The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …

The structure and functioning of multidrug efflux systems provide us with a better
understanding of the transport of various antibiotics, thus giving a path for the discovery of …

Abstract Multidrug-resistant (MDR) gram-negative bacteria pose significant challenges to the
public health. Various factors are involved in the development and spread of MDR strains …

Lichens produce secondary metabolites that have many pharmaceutical activities such as
antimicrobial, antioxidant, antiviral, anticancer, antigenotoxic, anti-inflammatory, analgesic …

Bacterial efflux pumps have emerged as antibiotic resistance determinants and confers multi-
drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A …

Efflux pumps have been reported as one of the significant mechanisms by which bacteria
evade the effects of multiple antibiotics. The tripartite efflux pump MexAB-OprM in …

Multidrug resistance pathogens causing infections and illness remain largely untreated
clinically. Efflux pumps are one of the primary processes through which bacteria develop …