[HTML][HTML] Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context

A Esmaeili, M Alini, M Baghaban Eslaminejad… - Stem Cell Research & …, 2022 - Springer
Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to
efficiently treat diseases. Promising features of EVs include their innate therapeutic …

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

D Ingato, JU Lee, SJ Sim, YJ Kwon - Journal of controlled release, 2016 - Elsevier
Extracellular vesicles (EVs) hold great promise as potential therapeutic carriers. EVs are
biologically active, intrinsically transporting cargo between cells. Moreover, they can be …

Extracellular vesicles: Emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy

M Wu, M Wang, H Jia, P Wu - Drug Delivery, 2022 - Taylor & Francis
Increasing evidences show that unmodified extracellular vesicles (EVs) derived from various
cells can effectively inhibit the malignant progression of different types of tumors by …

Extracellular vesicles for improved tumor accumulation and penetration

N Bie, T Yong, Z Wei, L Gan, X Yang - Advanced drug delivery reviews, 2022 - Elsevier
Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …

[HTML][HTML] Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Q Liu, D Li, X Pan, Y Liang - Journal of nanobiotechnology, 2023 - Springer
Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

[HTML][HTML] Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Generation, purification and engineering of extracellular vesicles and their biomedical applications

J Gao, X Dong, Z Wang - Methods, 2020 - Elsevier
Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be
excellent therapeutics and drug carriers. Although EVs are promising, the process to …

[HTML][HTML] Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

SAA Kooijmans, OG de Jong, RM Schiffelers - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins,
nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another …

New approaches in extracellular vesicle engineering for improving the efficacy of anti-cancer therapies

MK Jayasinghe, M Tan, B Peng, Y Yang, G Sethi… - Seminars in Cancer …, 2021 - Elsevier
Cancer is a disease that evolves continuously with unpredictable outcomes. Although
conventional chemotherapy can display significant antitumor effects, the lack of specificity …

[HTML][HTML] Extracellular vesicles as drug transporters

M Nowak, J Górczyńska, K Kołodzińska… - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and
synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and …